Cardiopulmonary Resuscitation–associated Lung Edema (CRALE). A Translational Study

Rationale: Cardiopulmonary resuscitation is the cornerstone of cardiac arrest (CA) treatment. However, lung injuries associated with it have been reported.Objectives: To assess 1) presence and characteristics abnormalities induced by cardiopulmonary 2) role mechanical manual chest compression (CC) in its development.Methods: This translational study included a porcine model CA (n = 12) multicenter cohort patients out-of-hospital undergoing or CC 52). Lung computed tomography performed after was assessed qualitatively quantitatively along respiratory mechanics gas exchanges.Measurements Main Results: The weight group higher compared experimental (431 ± 127 vs. 273 66, P 0.022) clinical (1,208 630 837 306, 0.006). showed significantly lower oxygenation (P 0.043) system compliance < 0.001) study. variation right atrial pressure (54 11 31 6 mm Hg, correlated (r 0.686, 0.026) −0.634, 0.027). Incidence abnormal density treated (37% 8%, 0.018).Conclusions: demonstrated resuscitation–associated edema animals CA, which more pronounced as opposed to correlates swings during CC.